Persistence on these treatments is not well understood in European PsA populations. Conclusions: Adherence and persistence to OACs are low at 1 year with heterogeneity across drugs and over time at individual and system levels. OAB medication prescription and 10.3% lower hazard of non-persistence with OAB medications during a 12-month evaluation period. Non-persistence was defined as a gap >180 days. The cohort included 7474 MS patients (72.2% female; mean age 38.9 years). Cox proportional hazards models were estimated to examine the adjusted hazard ratios (aHRs) of rivaroxaban vs. warfarin on non-persistence and discontinuation. Overall rates of 'primary non-adherence' (stopping after first prescription), 'non-adherent non-persistence' and 'persistent adherence' were 3.5%, 26.5% and 40.2%, differing across OACs. 2012 Nov;66(11):1042-51. doi: 10.1111/j.1742-1241.2012.03009.x. Methods: The study data… Non-adherence was calculated in persistent patients and defined as a medication possession ratio <80%. Among patients who discontinued, 23% switched to another prophylactic and 41% re-initiated therapy within one year. Non-persistence occurs when patients “don’t take their medication as long as prescribed”. Patients were followed for 5 years; those with a treatment gap period of at least 6 months without statin prescription were classified as "non-persistent". Poor medication adherence, or non-adherence, limits effective management and control of chronic illnesses. Non-adherence increases disease progression, increases hospitalizations, and increases avoidable doctor and emergency room visits. Increasing overall number of medications appeared as a protective factor associated with persistence in our study. Int J Clin Pract. With regard to the assessment of medication adherence the following information was extracted, the method for assessing medication adherence (using prescription/claims data, electronic monitoring, patient-reported, etc. (2011) reports on OACD therapy non-adherence rates between 0% and 84%. Cox regression hazard ratios (HRs) and logistic regression odds ratios (ORs) were assessed for sociodemographic and medication-related factors as possible predictors. Adherence: a Medication Possession Ratio (MPR) >80%. Conclusion: Non-adherence and non-persistence to oral anticancer drug therapy are complex phenomena. 11 The terms non-persistence and early discontinuation are used interchangeably in the literature. Results. Medication non-adherence as a cause of hospital admissions Farm Hosp . A better understanding of factors associated with non-adherence may provide targets to intervene and improve medication persistence. One of the most frequent causes of non … ), the component of medication adherence studied (adherence, non-persistence, time until non-persistence, etc. Amitriptyline, gabapentin, and nortriptyline had significantly higher likelihood of non-persistence compared with topiramate. The hazard of non-persistence of the inhaled therapy was increased compared with that of the oral therapy (HR=1.23, p=0.043). The Medication Adherence and Persistence Special Interest Group will develop good research practice recommendations for the conduct of medication adherence and treatment persistence research studies and will provide insight, through systematic reviews of the medication adherence literature, on interventions that improve medication adherence. Medication persistence was defined as absence of refill gap of ≥60 days. Older and younger age, and the influence of therapy related side effects were found to be predominant factors. • 51% of insured Americans take at least one medication – 50% of those do not take medications as prescribed • Medication non-adherence costs around $290 billion in healthcare costs • Literature on non-adherence – 24% post-MI did not fill medications within 7 days – 21% prescribed aspirin, beta-blocker, and statin after CAD diagnosis Introduction: Non-persistence (stopping medication prematurely) and non-compliance (not taking medications at the prescribed times) with oral medications to prevent osteoporotic fractures is widespread and attenuates their fracture reduction benefit. Non persistence is rarely intentional and happens when patients and providers miscommunication about therapeutic plans. Missing or delaying medication because of financial concerns is common; however, the effects of treatment during the follow-up. After two years, the researchers saw that the Medicare Part D subsidy reduced medication non-adherence and non-persistence in all race demographics. Results: At the end of the 3-year follow-up period, 1184 (27.4%) patients were considered non-persistent with antiplatelet medication. Conclusions Adherence to antihypertensive drugs in patients on oral diabetes drugs has improved over time. A literature review by Foulon et al. Comparative persistence and adherence to overactive bladder medications in patients with and without diabetes. Sixty-nine percent of black patients, 70 percent of Hispanic patients, and 61 percent of white patients had reached medication persistence by that point. The adjusted hazard ratio of non-persistence with ADs was 1.52 (95% confidence interval 1.41–1.63). Better understanding of contributory factors will inform … Introduction Prescription costs are rising, and many patients with chronic illnesses have difficulty paying for prescriptions. Conclusion In addition to the clinical and virological profiles of influenza infection, non-persistence may have been influenced by an active combination and the route of administration. TNF inhibitors (TNFis) and IL inhibitors are effective treatments for PsA. Non-persistence. Admissions due to medication non-adherence are associated with an important depletion of economic resources in the hospital. Treatment non-persistence (drug survival, discontinuation) is a measure of effectiveness, tolerability and patient satisfaction or preferences in real-world clinical practice. Research suggests this may be due to the impact of HT side effects. Interestingly, the conventional socioeconomic risk factors for medication non-adherence, such as household income, type of insurance, and residential area [40,41,42] were not predictive of APT non-persistence after ischemic stroke in the patients aged 75 years and older. Despite these clinical benefits, rates of HT non-adherence and non-persistence are high. It is mostly unintentional in nature and arises out of miscommunication on therapeutic plans between the provider and patient. Persistence of biologic therapy in psoriatic arthritis (PsA) patients is an important factor in individualized patient treatment planning and healthcare policy and guideline development. RCT registration number NCT00799760. Surprisingly, non‐persistence on PrEP medication was only moderately attenuated in the second year (37% non‐persistence in year 2, compared to 44% non‐persistence in year 1). Stroke patients in particular can benefit from pharmacotherapy for thrombosis, hypertension, and dyslipidemia but are at high risk for medication nonpersistence. In their study, non-persistence was defined as an absence of medication refilling within 30 days from the run-out date of the prior prescription. Time to non-persistence was calculated by the number of days on index DMT treatment before the first treatment gap (≥90 days) or switch and analyzed with time-to-event methodology. abstract . Key advantages of direct oral anticoagulants (DOAC) are efficacy (at least as good as observed with warfarin), rare intracerebral bleeding events, and the absence of close monitoring requirements (Rivera-Caravaca et al., 2017). Early non-persistence is a risk factor for not reinitiating treatment. A retrospective cohort study design was used following patients from the index date to the occurrence of non-persistence with the index medication (i.e., a gap of greater than 45 days between successive prescription fills or a switch to any other OAB medication), or the end of a 1-year follow-up period, through December 31, 2004. Medication non-adherence affects therapeutic efficacy and positive health outcomes for patients across a variety of chronic conditions, including attention-deficit/hyperactivity disorder (ADHD). Time to non-persistence was defined as the number of days between the date of the first dispense of a drug to the theoretical end date of the last dose of that drug, if a patient would take the drug exactly as prescribed. Medication nonadherence can be as high as 50% and results in suboptimal patient outcomes. MPR is defined as the total days covered by the medication/total days needing the medication. Among patients with depression, independent factors associated with nonpersistence included younger age at oral AD initiation (o45 years) and starting treatment with drugs other than metformin (especially Secondary: This type has more to do with non-persistence, where a patient stops medication on his own accord after starting it. 1. Associated factors influencing medication non-adherence and non-persistence to oral anticancer drugs are multifactorial and interrelated. Our study was aimed at 1) the analysis of non-persistence with antiplatelet medication in older PAD patients and 2) identification of patient- and medication-related characteristics associated with non-persistence. In 1244 (28.8%) patients, a switch in the use of a … Adherence was calculated using proportion of days covered (PDC) (cutoff ≥0.8). Patients with a 6-month treatment gap without antiplatelet medication prescription were designated as non-persistent, and the Cox proportional hazards model was used to identify predictors of non-persistence. This finding has substantial implications for PrEP retention programmes: sustained efforts are needed to retain PrEP users throughout their first two years of medication, and possibly for longer periods of time. Conclusions: Patients with diabetes were more persistent and adherent to OAB medications and had higher odds of filling a second medication … The first year after initiation is the most crucial with regard to non-adherence and non-persistence, and the risk groups are different for both processes. A second type of non adherence is called non persistence in which patients decide to stop taking a medication after starting it, without being advised by a health professional to do so. Efforts to quantify antihypertensive medication non-persistence are needed, especially when considering the current and future burden of this chronic disease . However, despite these benefits, a significant number of treated atrial fibrillation (AF) patients will experience (recurrent) stroke (Ruff et al., 2015; Shinoda et al., 2018). Non-adherence is considered to be a serious public health issue, [ 13] presenting challenges not only to affected individuals, but to clinicians … Discontinuation was defined as no additional refill for at least 90 days and until the end of follow-up. Patients who were admitted to the Queen Elizabeth II Health Sciences Centre in Halifax, Nova Scotia, with stroke between January 1, … Non-persistence = a gap of ≥90 days between medication refills: Using prescription fill and refill data: Rate of prescription fill was 64% and 70% for those with hormone receptor-positive tumours. Medication adherence has been proposed to consist of three phases: patient initiation, implementation, and discontinuation (non-persistence) . To estimate the persistence of biologic agents prescribed to PsA patients in a real-life setting as well as factors associated with improved biologic drug survival in these patients. UNLABELLED: Our objective was to assess the association of self-reported non-persistence (stopping fracture-prevention medication for more than 1 month) and self-reported non-compliance (missing doses of prescribed medication) with perceived need for fracture-prevention medication, concerns regarding long-term harm from and/or dependence upon medications, and medication-use …

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